Irvingia gabonensis seed extract The Irvingia gabonensis seed comes from a tree indigenous to West Africa and contains 7.5% protein, 14% fiber, 50% fat, and 2.3% ash. It is high calcium, iron, thiamin, riboflavin and niacin. The healthy fatty acids include myristic, lauric, stearic, palmitic and oleic acids. In a month long 2005 study of 40 people, the high soluble fiber content of IG was found to help lower total cholesterol, LDL, triglycerides and raise HDL levels. 

Glycoproteins of the mango seeds are believed to inhibit hydrolase enzymes which may explain its blood sugar lowering effect. 

Alpha-amylase inhibitors are believed to slow digestion and break down of starch, reducing blood sugar levels and insulin resistance.

IGOB131 is believed to has inhibitory effect on adipogenesis through the down-regulation of adipogenic transcription factors (PPAR gamma and glycerol-3 phosphate dehydrogenase) in addition to beneficial down-regulation of leptin and up-regulation of adiponectin.

PPAR gamma gene is known to contribute to obesity.

Adiponectin is shown to be anti-atherogenic, anti-diabetic and anti-inflammatory.5 

Raspberry ketones, a phenolic compound found in red raspberries, are similar in structure to other known anti-obesity compounds, capsaicin and synephrine. In a 2005 in vivo study mice were fed a high fat diet and given RK. RK prevented elevations in weights of liver and visceral adipose tissues. Norepinephrine lipolysis was also increased compared to controls. 7 The study suggests that RK can be used to prevent and improve obesity and fatty liver disease.

A more recent in vitro study of adipocytes sought to determine the mechanism of action of raspberry ketones. RK was found to increase the expression and secretion of adiponectin, increase fatty acid oxidation and suppress lipid accumulation in adipocytes.8

The active ingredient of Green coffee bean extract is chlorogenic acid, which studies show has an effect on glucose and fat metabolism in the body. In animal studies green coffee beans delayed absorption of fats and certain sugars from the intestine. Also it was shown to activate fat metabolism in the liver. In obese rats glucose tolerance was improved.

Dosage: As a nutritional supplement, two veggie caps daily, one cap with breakfast, and one cap 15 minutes before lunch or dinner.