Research Studies on Ingredients of Endokrium

Group I. Phytonutrients that regulate the endocrine system:

• Sage dried extract (Salvia officinalis L.) (leaf) >2.5% rosmarinic acid 52 mg
  • Features: Sage is renowned for its antioxidant and anti-inflammatory properties.
  • Benefits: May enhance cognitive abilities, reduce menopausal symptoms, and support overall brain health.
  • References: Effect of Salvia officinalis on diabetic patients.
• Cimicifuga dried extract (Cimicifuga racemosa L.,root) >2.5% Triterpene glycosides 70 mg
  • Features: Contains natural compounds that exhibit estrogen-like effects.
  • Benefits: Often used to manage menopausal symptoms, PMS, and to promote overall female reproductive health.
  • References: Black cohosh (Cimicifuga spp.) for menopausal symptoms.
• Rosemary dried extract (Rosmarinus officinalis L.) (leaves) >2% rosmarinic acid 22 mg
  • Features: Known for its rich antioxidant and anti-inflammatory content.
  • Benefits: Might support memory function, and circulation, and protect the nervous system.
  • References: Rosemary supplementation improves memory in rodents.
• Red clover dried extract (Trifolium pretense L.) (herb) >20% Isoflavones 18 mg
  • Features: Red clover is rich in isoflavones which mimic estrogen in the body.
  • Benefits: May alleviate symptoms of menopause, support bone health, and promote heart health.
  • References: Effects of red clover on hot flash and circulating hormone concentrations.
• Dried Angelica (Angelica archangelica L.) (root) 13 mg
  • Features: Contains compounds known to have anti-spasmodic and expectorant properties.
  • Benefits: Often used to treat various digestive issues and respiratory conditions.
  • References: The pharmacological activities of Angelica archangelica.
• Yarrow (Achilea millefolium L.) (herb) >0.02% chamazulene 4 mg
  • Features: Yarrow has anti-inflammatory, antispasmodic, and astringent properties.
  • Benefits: Traditionally used to treat wounds, and digestive problems, and to reduce inflammation.
  • References: Anti-inflammatory activity of Achillea millefolium.
• Fennel dried extract (Foeniculum vulgare Mill.) (fruit) >0.25% Anethol 4 mg
  • Features: Fennel is known for its anti-inflammatory, anti-spasmodic, and diuretic properties.
  • Benefits: Often utilized to treat bloating, gas, and other digestive issues.
  • References: Effect of Fennel on primary dysmenorrhea.

Group II. Adaptogenic and nutritional preparations:

• Maca dried extract (LepidiummeyeniiWalp.) (root) ratio 4:1) 79mg
  • Features: A root vegetable indigenous to the Andes, recognized as an adaptogen and rich in essential amino acids, iodine, iron, and magnesium.
  • Benefits: Supports hormonal balance, boosts energy levels, and may enhance sexual health and fertility.
  • References: Effect of Maca supplementation on mood and anxiety.
• Triphala dried extract (Emblica officinalis, Terminalia chebula, and Terminalia bellirica fruits, 30% tannins) 18mg
  • Features: A traditional Ayurvedic formulation comprising three fruits, known for its rich antioxidant properties.
  • Benefits: Supports digestive health, promotes detoxification, and may enhance skin health.
  • References: Efficacy of Triphala in maintaining oral health.
• Ashwagandha or Withania dried extract (Withania somnifera, root, 1.5% withanolides) 13mg
  • Features: A renowned adaptogenic herb central to Ayurvedic medicine.
  • Benefits: Assists in stress reduction, supports cognitive function, and may improve physical performance.
  • References: Impact of Ashwagandha on stress and cognition.

Group III. Amino acids:

• L-Proline 30mg
  • Features: An amino acid essential for collagen synthesis.
  • Benefits: Supports skin health and elasticity, promotes joint health, and aids wound healing.
  • References: Role of proline in skin health.
• L-Aspartic Acid 18mg
  • Features: An amino acid that plays a crucial role in the tricarboxylic acid cycle and deamination of amino acids.
  • Benefits: Supports energy production and neurotransmitter synthesis.
  • References: Studies on Aspartic Acid metabolism.
• Gamma-aminobutyric acid (GABA) 13 mg
  • Features: A primary inhibitory neurotransmitter in the central nervous system.
  • Benefits: Assists in reducing anxiety, promotes relaxation, and improves sleep.
  • References: Role of GABA in anxiety and depression.
• L-Citrulline-DL-Malate 13 mg
  • Features: An amino acid that assists in the production of nitric oxide.
  • Benefits: Enhances blood flow, supports heart health, and may improve exercise performance.
  • References: Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils.
• L-Glutamic Acid 9mg
  • Features: An amino acid vital for metabolic processes and neurotransmission.
  • Benefits: Supports cognitive function and plays a role in the body’s energy production.
  • References: Role of Glutamate in neuroscience.
• L-Tyrosine 4mg
  • Features: An amino acid precursor to several neurotransmitters, including dopamine, norepinephrine, and epinephrine.
  • Benefits: Can support mental alertness, focus, and mood.
  • References: Tyrosine and cognitive performance.

Group IV. Minerals:

• Tricalcium phosphate (38.76% Calcium, 19.97%Phosphorus) 40mg
  • Features: A major source of calcium and phosphorus.
  • Benefits: Essential for bone health and dental health, and aids cellular function.
  • References: Calcium and bone health.
• Magnesium malate (>20% magnesium) 15mg
  • Features: A compound formed from magnesium and malic acid.
  • Benefits: Supports energy production, muscle and nerve function, and may alleviate symptoms of fibromyalgia.
  • References: Effects of magnesium malate on fibromyalgia symptoms.
• Zinc gluconate (14.34% zinc) 10mg
  • Features: A common form of zinc supplementation.
  • Benefits: Vital for immune system function, protein synthesis, wound healing, and DNA synthesis.
  • References: Zinc and immune function.
• Copper gluconate (13.88% copper) 1mg
  • Features: A form of the essential mineral copper.
  • Benefits: Important for iron metabolism, energy production, and neurotransmitter synthesis.
  • References: Copper in human health.
• Manganese gluconate (11.42% manganese) 0.5mg
  • Features: A source of the trace mineral manganese.
  • Benefits: Vital for bone formation, blood clotting, and reducing oxidative stress.
  • References: Manganese in metabolism and enzyme function.

Group V. Metabolic Regulators:

• Adenosine 5′-monophosphate (AMP) 1mg
  • Features: A nucleotide and a cellular energy currency.
  • Benefits: Involved in many cellular processes including energy transfer and signal transduction.
  • References: Role of AMP in cellular metabolism and ATP synthesis.
• Sodium hyaluronate 1mg
  • Features: The sodium salt form of hyaluronic acid.
  • Benefits: Supports skin hydration, aids wound healing, and is beneficial for joint health.
  • References: Clinical use of hyaluronic acid.

Group VI. Phospholipids and Vitamins:

• Beta-carotene (>10% beta-carotene) 14.4mg
  • Features: A carotenoid and precursor to Vitamin A.
  • Benefits: Antioxidant properties, supports skin health, and promotes good vision.
  • References: Beta-carotene and human health.
• Soy lecithin (Glycine soja, values: phosphatidylcholine 18-25% phosphatidylethanolamine 10-16%, phosphatidylinositol 14-19%) 10mg
  • Features: A complex mixture of phospholipids derived from soy.
  • Benefits: Supports brain function, promotes liver health, and is used as an emulsifying agent.
  • References: Neurological effects of soy lecithin.
• Vitamin E (Tocopheryl Acetate 50% vitamin E, 500-600 I.U./g) 7.2mg
  • Features: A fat-soluble antioxidant.
  • Benefits: Protects cells from oxidative stress, supports immune function, and promotes skin health.
  • References: Vitamin E in dermatology.
• Pyridoxal 5′-phosphate (Vitamin B6, 63.82 pyridoxine) 0.66mg
  • Features: The active form of Vitamin B6.
  • Benefits: Essential for neurotransmitter synthesis, hemoglobin synthesis, and energy metabolism.
  • References: Vitamin B6 in health supplements.
• Thiamine hydrochloride hlc (Vitamin B1, 78.67 thiamin) 0.42mg
  • Features: A water-soluble vitamin.
  • Benefits: Crucial for energy metabolism, supports nerve function, and aids in the synthesis of certain neurotransmitters.
  • References: Thiamine in clinical practice.
• Folic acid (pteroylmonoglutamic acid) 0.1mg
  • Features: A type of B-vitamin.
  • Benefits: Vital for DNA synthesis, supports fetal development, and helps in the formation of red blood cells.
  • References: The importance of folic acid.