OBSERVATIONAL PROSPECTIVE STUDY
OF HOMEOPATHIC TREATMENT IN
PATIENTS WITH MIGRAINE, ATTENDING
THE HEADACHE CLINIC OFNEUROLOGY
ATHENS GENERAL HOSPITAL
S.Kivellos , J.Papatriantafyllou
, K.Papilas , G.Vithoulkas ,
BACKGROUND AND AIMS.
Homeopathy trials of migraine
prevention have yielded inconclusive
results, partly due to different
practice among various schools.
We performed an observational
prospective study of classical
homeopathy in patients attending
the Cephalalgia Clinic.
consecutive patients who attended
the clinic while one of the
authors was available were assigned
to receive homeopathic treatment,
according to the principles
recommended by the I.A.C.H.
and G.Vithoulkas. Additional
evaluation by a neurologist
was performed at baseline, 6
and 12 months. Primary and secondary
measures of migraine severity
and impact on quality of life
were recorded and analyzed.
patients opted only for homeopathic
treatment until the completion
of the study, aged (mean±SD)
34±12 years, with a baseline
HIT-6 score of 65±4.
Significant improvement was
recorded at 6 months (HIT-6
48±8, P<0.0009 vs
baseline, Wilcoxon signed ranks
test), which was further established
at 12 months (HIT-6 41.2±7,
P<0.0009 vs 6-months). Eighteen
patients had been previously
administered TCAs or antiepileptics
for sufficient time without
remarkable improvement. A difference
in HIT-6 score between those
‘resistant’ to previous
therapy and ‘new’
patients was found at six months
(51.5±7 vs 44.5±7,
respectively, P<0.01, Mann-Whitney
test), but not at baseline (66±3.8
vs 64±4, respectively)
or after 12 months (41.6±8
vs 40.6±5.3, respectively).
Migraine severity (VAS) decreased
by 72% and frequency by 81 %
at 12 months (P<0.0001 for
both comparisons vs baseline).
Mood was consistently higher
at 12 months (Verbal Analogue
Scale, P<0.001). Observed
potential adverse effects on
all 42 patients were an initial
migraine symptoms in 69%, recurrence
of past medical diseases (e.g.
infections, eczema) in 33%,
temporary emotional instability
in 59% of the patients.
These results compare favorably
with other modalities of migraine
treatment. Therefore, homeopathy,
as applied in this context,
warrants further research with
appropriately designed RCTs.