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Clinical
efficacy of "HERPIGEN" in management
of the female herpes genitalis Doschanova
A.M. - State National Medical University,
Almaty
AIM: To assess efficacy of "HERPIGEN",
an anti-viral preparation in management
of females with herpes genitalis.
Materials and methods
22 females aged from 21 to 38 with clinical implications of
herpetic viral infection comprised the group under observation.
The infection presence was confirmed by the performed DNA
PCR analysis. The patients' complaints and medical histories
were studied with the examination of immunological status
(A-, G- and M-class immunoglobulins). The PCR was employed
in herpetic virus typing. We managed to assess the preparation
efficacy, side effects and complications, presence or absence
of ulcerous erosions and recurrence rate of herpetic viral
infection.
Method of administration
The performed monotherapy comprised spraying of the skin surface
and mucous membranes with "HERPIGEN" 6 times a day for 5-7
days. The females were followed-up 7-10 days after the therapy
and further with onemonth interval for 6 months.
Patients' characteristics: 22 females with clinical implications
of herpetic viral infection in exacerbation were examined
and managed on the outpatient basis. All the females above
had recurring herpes genitalis with various disease duration:
the one of less than one year (n=14), from 1 to 5 years (n=6),
6-10 years (n=2). The disease recurrence rate was as follows:
once a month (n=5), one time per two months (n=8), one times
per three months (n=9). In 7 of 22 patients the rash was registered
accompanied by hyperthermia (up to 37.5 degrees of Centigrade),
fever, general indisposition and regional lymphadenitis.
Results: the findings of the performed clinical trial are
indicative of high "HERPIGEN" efficacy in management of herpetic
infections. 20 patients stopped complaining of itch and burning
on the 2nd day of the therapy. The reduction of the complaints
was observed in 2 females to terminate in all of the patients
on the 3rd day of the therapy. First intention and herpetic
erosion epithelization were detected to take place on the
2nd day and in the first 3 days of the therapy, respectively.
The clinical effect absence was not registered in the management
of herpetic affections. The increase in serum IgM was found.
Reexamination a month after the therapy revealed no herpes
simplex virus in 10 patients, 6 months after the therapy -
in 5 more females. 6-month follow-up showed the recurrences
in 5 persons. Neither allergic reactions nor side effects
were registered.
Conclusion
"HERPIGEN" is a highly efficient, handy and tolerable preparation
for external use in management of herpetic infection implications,
causing no sides effects. The preparation can be recommended
for wide use in medical practice. Slides
1. Advantages of administration in pregnancy:
The "HERPIGEN INTIM" spray - requires no special medical skills,
being handy and easy in use without assistance;
produces rapid therapeutic effect; - being natural, produces
no allergic and side reactions; - evokes no skin irritation,
producing fine sanitizing effect; - is rapidly absorbed, being
easily removed and leaving no stains on clothes; - has no
embryotoxic and teratogenic effect with safety confidently
experimentally and clinically confirmed.
2. Indication of use
Management of herpes viral infection caused by herpes
simplex virus both in acute primary and in recurring course.
· Herpes viral infection recurrence prevention. ·
Management of lichen shingles caused by Varicella -Zoster
virus (in complex therapy). · Therapy of cytomegalovirus.
· Management of papillomavirus infection caused by
various types (oncogenic included), of human papilloma virus.
· Therapy of non-specific colpitis and vaginosis, vaginal
microflora normalization. · As prophylactic anti-viral
and anti-
inflammatory
preparation in sexual intercourse
5. Glycyrrhizic acid is a kinase inhibitor.
It produces: · Anti-viral effect. · Anti-flammatory
effect. · Anti-ulcerous effect · Anti-bacterial
(bacteriostatic) effect · Interferogenic effect ·
Immunemodulating effect · Antipruritic effect ·
Produces rapid effect · Produces no side effect ·
Prolongs remission · Is absolute rapidly
6. HERPIGEN
Pharmacological peculiarities and mechanism of action. Glycyrrhizic
acid is an essential active agent
Mechanism of action:
Glycyrrhizic acid inhibites DNA and RNA of :
Herpes simplex virus, Varicella -zoster, Hepatitis
A virus, Influenza virus, Vesicular stomatitis virus, Human
immunodeficiency virus
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